CD8 Antikörper (APC)

Produktnummer ABIN272356

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD8 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD8 Antikörper (APC) (ABIN272356)

Target: CD8

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: MEM-31

Produktdetails anti-CD8 Antikörper (APC)

Spezifität: This antibody recognizes a conformationally-dependent epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 is a disulfide-linked dimer and exists as a CD8α homodimer or CD8α/β heterodimer (each monomer approx. 32-34 kDa).

Produktmerkmale: Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain

Immunogen: Crude thymus membrane fraction

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole bloodor 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. The antibody does not react with formaldehyde-fixed cells, negative in Western Blottingapplication.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD8

Target: CD8

Andere Bezeichnung: CD8

Hintergrund: The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as αβ heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as αα homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8β level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 α-β but not α-α dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2

Gen-ID: 925

UniProt: P01732